Induction of Apoptotic Cell Death by Tyrosine Kinase Inhibitor

Induction of apoptotic cell death by putrescine.

The polyamines are essential for cellular growth and differentiation. Ornithine decarboxylase (ODC), which catalyses the first step in the biosynthesis of the polyamines, has a very fast turnover and is subject to a strong feedback control by the polyamines. In the present study, we show that overexpression of a metabolically stable ODC in CHO cells induced a massive cell death unless the cells...

Cell death induction by Streptococcus pyogenes in four types of malignant cell lines

  Abstract   Background: The interest in using bacteria as anti- cancer therapeutic agents dates back to the end of the19th century. Some bacteria like Salmonella and Listeria replicate effectively inside malignant cell lines and suppress their growth. The bacterium Streptococcus pyogenes has become medically famous as a flesh-eating pathogen since mid-1980s. It is the causative agent of a life...

induction and determination of apoptotic and necrotic cell death by cadmium chloride in testis tissue of mouse

background: cadmium chloride which is potentially toxic is currently used in industry. the toxic effects of cadmium on testes have been reported to range from apoptosis to necrosis, with different effects on fertility. this research aimed to study the effect of different doses of cadmium on testicular tissues at acute stage by light and electron microscopy. methods: cadmium chloride was injecte...

Direct Induction of Autophagy by Atg1 Inhibits Cell Growth and Induces Apoptotic Cell Death

BACKGROUND To survive starvation and other forms of stress, eukaryotic cells undergo a lysosomal process of cytoplasmic degradation known as autophagy. Autophagy has been implicated in a number of cellular and developmental processes, including cell-growth control and programmed cell death. However, direct evidence of a causal role for autophagy in these processes is lacking, resulting in part ...

Induction of Endoplasmic Reticulum Stress Death through a Process Involving The Kinase Inhibitor Sorafenib Induces Cell